Clitocybin A, a Novel Isoindolinone, From the Mushroom Clitocybe aurantiaca, Inhibits Cell Proliferation Through G1 Phase Arrest by Regulating the PI3K/Akt Cascade in Vascular Smooth Muscle Cells

• Main Authors: Kyu-Dong Yoo (Author), Eun-Seok Park (Author), Yong Lim (Author), Shin-Il Kang (Author), Su-Hyang Yoo (Author), Ha-Hee Won (Author), Young-Hee Kim (Author), Ick-Dong Yoo (Author), Hwan-Soo Yoo (Author), Jin Tae Hong (Author), Yeo-Pyo Yun (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abnormal proliferation of vascular smooth muscle cells (VSMCs) plays an essential role in the pathogenesis of vascular diseases, such as atherosclerosis, hypertension, and restenosis. Clitocybin A, a novel isoindolinone, isolated from the culture broth of mushroom Clitocybe aurantiaca has been repor...