Structural basis for antibody recognition of the proximal MUC16 ectodomain

• Main Authors: Kwangkook Lee (Author), Kay Perry (Author), Mengyao Xu (Author), Irva Veillard (Author), Raj Kumar (Author), Thapi Dharma Rao (Author), Bo R Rueda (Author), David R Spriggs (Author), Oladapo O Yeku (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mucin 16 (MUC16) overexpression is linked with cancer progression, metastasis, and therapy resistance in high grade serous ovarian cancer and other malignancies. The cleavage of MUC16 forms independent bimodular fragments, the shed tandem repeat sequence which circulates as a pro...