Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated by <i>MnSOD</i> Ala-9Val Gene Polymorphism

• Main Authors: Dong Mei Wang (Author), Rong Rong Zhu (Author), Yang Tian (Author), Kadir Uludag (Author), Jia Jing Chen (Author), Hui Xia Zhou (Author), Li Wang (Author), Thomas R. Kosten (Author), Xiang Yang Zhang (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The imbalance between pro-oxidants and antioxidants is thought to be responsible for aging and cognitive impairment in many degenerative diseases, including schizophrenia (SZ). As the first antioxidant enzyme to detoxify superoxide radicals in mitochondria, manganese superoxide dismutase (MnSOD) act...