Cardiac safety implications of hNav1.5 blockade and a framework for preclinical evaluation

Cardiac safety implications of hNav1.5 blockade and a framework for preclinical evaluation

The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced sodium channel inhibition decreases the rate of cardiomyocyte depolarization and consequently conduction velocity and can have serious implicat...

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Main Authors: Gul eErdemli (Author), Albert M Kim (Author), Haisong eJu (Author), Clayton eSpringer (Author), Robert C Penland (Author), Peter K Hoffmann (Author)
Format: Book
Published: Frontiers Media S.A., 2012-01-01T00:00:00Z.
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3rd Floor Main Library

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