Cardiac safety implications of hNav1.5 blockade and a framework for preclinical evaluation

• Main Authors: Gul eErdemli (Author), Albert M Kim (Author), Haisong eJu (Author), Clayton eSpringer (Author), Robert C Penland (Author), Peter K Hoffmann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced sodium channel inhibition decreases the rate of cardiomyocyte depolarization and consequently conduction velocity and can have serious implicat...