Discovery of novel and potent dual-targeting AXL/HDAC2 inhibitors for colorectal cancer treatment via structure-based pharmacophore modelling, virtual screening, and molecular docking, molecular dynamics simulation studies, and biological evaluation

• Автори: Xiao Qiao (Автор), Xiangyu Wu (Автор), Shutong Chen (Автор), Miao-Miao Niu (Автор), Huilian Hua (Автор), Yan Zhang (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

AbstractColorectal cancer (CRC) is one of the most common cancers worldwide. Nowadays, owing to the complex mechanism of tumorigenesis, simultaneous inhibition of multiple targets is an important anticancer strategy. Recent studies have demonstrated receptor tyrosine kinase AXL (AXL) and histone dea...