Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies

• Main Authors: Halilibrahim Ciftci (Author), Belgin Sever (Author), Esra Ayan (Author), Mustafa Can (Author), Hasan DeMirci (Author), Masami Otsuka (Author), Amaç Fatih TuYuN (Author), Hiroshi Tateishi (Author), Mikako Fujita (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The HIV-1 Gag protein binds to the host cell membrane and assembles into immature particles. Then, in the course of immature virion budding, activated protease cleaves Gag into its main components: MA, CA, NC, and p6 proteins. The highly basic residues of MA predominantly interact with the acidic he...