Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting

• Main Authors: Dheeraj Kumar Posa (Author), Janice Miller (Author), David Hoetker (Author), Michael I. Ramage (Author), Hong Gao (Author), Jingjing Zhao (Author), Benjamin Doelling (Author), Aruni Bhatnagar (Author), Stephen J. Wigmore (Author), Richard J.E. Skipworth (Author), Shahid P. Baba (Author)
• Format: Book
• Published: Wiley, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Muscle wasting during cancer cachexia is mediated by protein degradation via autophagy and ubiquitin‐linked proteolysis. These processes are sensitive to changes in intracellular pH ([pH]i) and reactive oxygen species, which in skeletal muscle are partly regulated by histidyl dip...