A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits

• Main Authors: Ting Cao (Author), MiMi Tang (Author), Pei Jiang (Author), BiKui Zhang (Author), XiangXin Wu (Author), Qian Chen (Author), CuiRong Zeng (Author), NaNa Li (Author), ShuangYang Zhang (Author), HuaLin Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ketamine exposure can model cognitive deficits associated with schizophrenia. Progesterone (PROG) and its active metabolite allopregnanolone (ALLO) have neuroprotective effects and the pathway involving progesterone receptor membrane component 1 (PGRMC1), epidermal growth factor receptor (EGFR), glu...