Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation

• Main Authors: Fan Wu (Author), Qingqing Shao (Author), Zhe Cheng (Author), Xinyu Xiong (Author), Ke Fang (Author), Yan Zhao (Author), Ruolan Dong (Author), Lijun Xu (Author), Fuer Lu (Author), Guang Chen (Author)
• Format: Book
• Published: BMC, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) of necroptotic signal molecule receptor-interacting serine-threonine kinase 3 (RIPK3) was r...