Ligand-based design and synthesis of N'-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approaches with SAR studies

• المؤلفون الرئيسيون: Rogy R. Ezz Eldin (مؤلف), Marwa A. Saleh (مؤلف), Mohammad Hayal Alotaibi (مؤلف), Reem K. Alsuair (مؤلف), Yahya A. Alzahrani (مؤلف), Feras A. Alshehri (مؤلف), Amany F. Mohamed (مؤلف), Shaimaa M. Hafez (مؤلف), Azza Ali Althoqapy (مؤلف), Seham K. Khirala (مؤلف), Mona M. Amin (مؤلف), Yousuf A. F (مؤلف), Azza H. AbdElwahab (مؤلف), Mohamed S. Alesawy (مؤلف), Ayman Abo Elmaaty (مؤلف), Ahmed A. Al-Karmalawy (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Herein, a series of N'-benzylidene-3,4-dimethoxybenzohydrazide derivatives were designed and synthesised to target the multidrug efflux pump (MATE). The antibacterial activities were screened against S. aureus, Acinetobacter, S. typhi, E. coli, and P. aeruginosa, whereas their antifungal activi...