Ligand-based design and synthesis of N'-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approaches with SAR studies

• Main Authors: Rogy R. Ezz Eldin (Author), Marwa A. Saleh (Author), Mohammad Hayal Alotaibi (Author), Reem K. Alsuair (Author), Yahya A. Alzahrani (Author), Feras A. Alshehri (Author), Amany F. Mohamed (Author), Shaimaa M. Hafez (Author), Azza Ali Althoqapy (Author), Seham K. Khirala (Author), Mona M. Amin (Author), Yousuf A. F (Author), Azza H. AbdElwahab (Author), Mohamed S. Alesawy (Author), Ayman Abo Elmaaty (Author), Ahmed A. Al-Karmalawy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein, a series of N'-benzylidene-3,4-dimethoxybenzohydrazide derivatives were designed and synthesised to target the multidrug efflux pump (MATE). The antibacterial activities were screened against S. aureus, Acinetobacter, S. typhi, E. coli, and P. aeruginosa, whereas their antifungal activi...