Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors.

• Main Authors: Antonio C B Burtoloso (Author), Sérgio de Albuquerque (Author), Mark Furber (Author), Juliana C Gomes (Author), Cristiana Gonçalez (Author), Peter W Kenny (Author), Andrei Leitão (Author), Carlos A Montanari (Author), José Carlos Quilles (Author), Jean F R Ribeiro (Author), Josmar R Rocha (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Anti-trypanosomal activity against the CL Brener strain of T. cruzi was observed in the 0.1 μM to 1 μM range for three nitrile-based cysteine protease inhibitors ba...