Mechanism of Paeoniflorin on ANIT-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology

• Main Authors: Lisheng Chen (Author), Xu Zhao (Author), Shizhang Wei (Author), Xiao Ma (Author), Honghong Liu (Author), Jianyu Li (Author), Manyi Jing (Author), Min Wang (Author), Yanling Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Paeoniflorin (PF), the major active compound isolated from the roots of Paeonia lactiflora Pall., has been used in the treatment of severe hepatic diseases for several decades and displays bright prospects in liver protective effect. However, its biological mechanism that regulates bile...