The 'New (Nu)-clear' evidence of the tumor-driving role of PI3K

• Κύριοι συγγραφείς: Franklin Mayca Pozo (Συγγραφέας), Tony Hunter (Συγγραφέας), Youwei Zhang (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Compuscript Ltd, 2022-05-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The classical phosphatidylinositol 3-kinases (PI3Ks) are heterodimers of p110 and p85. PIK3CA, the gene encoding the catalytic p110α subunit, is one of the most frequently mutated oncogenes in human cancers. Mutations have been observed to occur in hotspots in the helical domain or kinase domain. Tu...