Computer-aided molecular design and optimization of potent inhibitors disrupting APC‒Asef interaction

• Главные авторы: Xuefei Wang (Автор), Zeqian Du (Автор), Yuegui Guo (Автор), Jie Zhong (Автор), Kun Song (Автор), Junyuan Wang (Автор), Jianqiang Yu (Автор), Xiuyan Yang (Автор), Chen-Ying Liu (Автор), Ting Shi (Автор), Jian Zhang (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2024-06-01T00:00:00Z.
• Предметы: article
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Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide. At initial diagnosis, approximately 20% of patients are diagnosed with metastatic CRC (mCRC). Although the APC‒Asef interaction is a well-established target for mCRC therapy, the discovery and development of effective...