Computer-aided molecular design and optimization of potent inhibitors disrupting APC‒Asef interaction

• Main Authors: Xuefei Wang (Author), Zeqian Du (Author), Yuegui Guo (Author), Jie Zhong (Author), Kun Song (Author), Junyuan Wang (Author), Jianqiang Yu (Author), Xiuyan Yang (Author), Chen-Ying Liu (Author), Ting Shi (Author), Jian Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide. At initial diagnosis, approximately 20% of patients are diagnosed with metastatic CRC (mCRC). Although the APC‒Asef interaction is a well-established target for mCRC therapy, the discovery and development of effective...