Penetration, distribution, and elimination of remofuscin/soraprazan in Stargardt mouse eyes following a single intravitreal injection using pharmacokinetics and transmission electron microscopic autoradiography: Implication for the local treatment of Stargardt's disease and dry age‐related macular degeneration

• Main Authors: Sylvie Julien‐Schraermeyer (Author), Barbara Illing (Author), Alexander Tschulakow (Author), Tatjana Taubitz (Author), Jamil Guezguez (Author), Michael Burnet (Author), Ulrich Schraermeyer (Author)
• Format: Book
• Published: Wiley, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Age‐related macular degeneration (AMD) is the leading cause of blindness in older people in the developed world while Stargardt's disease (SD) is a juvenile macular degeneration and an orphan disease. Both diseases are untreatable and are marked by accumulation of lipofuscin advancing...