Sigma-1 Receptor Inhibition Reduces Neuropathic Pain Induced by Partial Sciatic Nerve Transection in Mice by Opioid-Dependent and -Independent Mechanisms

• Main Authors: Inmaculada Bravo-Caparrós (Author), Gloria Perazzoli (Author), Sandra Yeste (Author), Domagoj Cikes (Author), José Manuel Baeyens (Author), Enrique José Cobos (Author), Francisco Rafael Nieto (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sigma-1 (σ1) receptor antagonists are promising tools for neuropathic pain treatment, but it is unknown whether σ1 receptor inhibition ameliorates the neuropathic signs induced by nerve transection, in which the pathophysiological mechanisms and response to drug treatment differ from other neuropath...