Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway

• Главные авторы: Siwen Liu (Автор), Suling Huang (Автор), Xingde Wu (Автор), Ying Feng (Автор), Yu Shen (Автор), Qin-shi Zhao (Автор), Ying Leng (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2020-11-01T00:00:00Z.
• Предметы: article
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Objective: Salt-induced kinase 1 (SIK1) acts as a key modulator in many physiological processes. However, the effects of SIK1 on gluconeogenesis and the underlying mechanisms have not been fully elucidated. In this study, we found that a natural compound phanginin A could activate SIK1 and further i...