Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development

• Main Authors: Maria E. Baardman (Author), Mathijs V. Zwier (Author), Lambertus J. Wisse (Author), Adriana C. Gittenberger-de Groot (Author), Wilhelmina S. Kerstjens-Frederikse (Author), Robert M. W. Hofstra (Author), Angelika Jurdzinski (Author), Beerend P. Hierck (Author), Monique R. M. Jongbloed (Author), Rolf M. F. Berger (Author), Torsten Plösch (Author), Marco C. DeRuiter (Author)
• Format: Book
• Published: The Company of Biologists, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipoprotein-related receptor protein 2 (LRP2) is important for development of the embryonic neural crest and brain in both mice and humans. Although a role in cardiovascular development can be expected, the hearts of Lrp2 knockout (KO) mice have not yet been investigated. We studied the cardiovascul...