Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives

• Main Authors: Rebeka Jójárt (Author), Seyyed Ashkan Senobar Tahaei (Author), Péter Trungel-Nagy (Author), Zoltán Kele (Author), Renáta Minorics (Author), Gábor Paragi (Author), István Zupkó (Author), Erzsébet Mernyák (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

2- or 4-Substituted 3-N-benzyltriazolylmethyl-13α-oestrone derivatives were synthesised via bromination of ring A and subsequent microwave-assisted, Pd-catalysed C(sp2)-P couplings. The antiproliferative activities of the newly synthesised brominated and phosphonated compounds against a panel of hum...