Adverse outcome pathways - development and potential regulatory application

• Main Authors: Thania Rios Rossi Lima (Author), Nathália Pereira de Souza (Author), Lílian Cristina Pereira (Author), João Lauro Viana de Camargo (Author)
• Format: Book
• Published: Fundação Oswaldo Cruz (FIOCRUZ), 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Over the last two decades, chemical safety assessment and regulatory toxicology have progressed from empirical science based on direct observation of apical adverse outcomes in whole organisms to a predictive practice that infers outcomes and risks on the basis of accumulated understan...