IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells

• Main Authors: Fadia R. Homaidan (Author), Marwan E. El-Sabban (Author), Iman Chakroun (Author), Mirvat El-Sibai (Author), Ghassan S. Dbaibo (Author)
• Formato: Livro
• Publicado em: Hindawi Limited, 2002-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels.