Mechanisms of Chronic Nicotine Treatment-Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons

• Main Authors: Yuki Takada-Takatori (Author), Toshiaki Kume (Author), Yasuhiko Izumi (Author), Tetsuhiro Niidome (Author), Takeshi Fujii (Author), Hachiro Sugimoto (Author), Akinori Akaike (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor is involved in this enhancement. In this stud...