Mechanisms of Chronic Nicotine Treatment-Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons

• Автори: Yuki Takada-Takatori (Автор), Toshiaki Kume (Автор), Yasuhiko Izumi (Автор), Tetsuhiro Niidome (Автор), Takeshi Fujii (Автор), Hachiro Sugimoto (Автор), Akinori Akaike (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2010-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor is involved in this enhancement. In this stud...