Mechanisms of Chronic Nicotine Treatment-Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons

• Principais autores: Yuki Takada-Takatori (Autor), Toshiaki Kume (Autor), Yasuhiko Izumi (Autor), Tetsuhiro Niidome (Autor), Takeshi Fujii (Autor), Hachiro Sugimoto (Autor), Akinori Akaike (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2010-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor is involved in this enhancement. In this stud...