Enhancement of Blood-Brain Barrier Permeability and Delivery of Antisense Oligonucleotides or Plasmid DNA to the Brain by the Combination of Bubble Liposomes and High-Intensity Focused Ultrasound

• Main Authors: Yoichi Negishi (Author), Masaya Yamane (Author), Naho Kurihara (Author), Yoko Endo-Takahashi (Author), Sanae Sashida (Author), Norio Takagi (Author), Ryo Suzuki (Author), Kazuo Maruyama (Author)
• Format: Book
• Published: MDPI AG, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The blood-brain barrier (BBB) is a major obstacle that prevents therapeutic drugs or genes from being delivered to the central nervous system. Therefore, it is important to develop methods to enhance the permeability of the BBB. We have developed echo-contrast gas (C3F8) entrapping liposomes (Bubble...