Utility of Physiologically Based Pharmacokinetic Modeling to Investigate the Impact of Physiological Changes of Pregnancy and Cancer on Oncology Drug Pharmacokinetics

• Principais autores: Xinxin Yang (Autor), Manuela Grimstein (Autor), Michelle Pressly (Autor), Elimika Pfuma Fletcher (Autor), Stacy Shord (Autor), Ruby Leong (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2023-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background: The treatment of cancer during pregnancy remains challenging with knowledge gaps in drug dosage, safety, and efficacy due to the under-representation of this population in clinical trials. Our aim was to investigate physiological changes reported in both pregnancy and cancer populations...