Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host.

• Main Authors: David Jessula Levy (Author), Amy Goundry (Author), Raquel S S Laires (Author), Tatiana F R Costa (Author), Carlos Mendes Novo (Author), Dennis J Grab (Author), Jeremy C Mottram (Author), Ana Paula C A Lima (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma brucei rhodesiense is one of the causative agents of Human African Trypanosomiasis (HAT), known as sleeping sickness. The parasite invades the central nervous system and causes severe encephalitis that is fatal if left untreated. We have previously identified ecotin-like inhibitors of se...