In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection.

• Main Authors: Ruklanthi de Alwis (Author), Martina Beltramello (Author), William B Messer (Author), Soila Sukupolvi-Petty (Author), Wahala M P B Wahala (Author), Annette Kraus (Author), Nicholas P Olivarez (Author), Quang Pham (Author), James D Brien (Author), Wen-Yang Tsai (Author), Wei-Kung Wang (Author), Scott Halstead (Author), Srisakul Kliks (Author), Michael S Diamond (Author), Ralph Baric (Author), Antonio Lanzavecchia (Author), Federica Sallusto (Author), Aravinda M de Silva (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Humans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for infection. Affected individuals also generate cross-reactive antibodies against heterologous DENV serotypes, which are non-neutralizing. Dengue cros...