2D-QSAR and CoMFA Models for Antitubercular Activity of Scalarane-Type Sesterterpenes

• Main Authors: Suriyan Thengyai (Author), Yuewei Guo (Author), Khanit Suwanborirux (Author), Heinz Berner (Author), Helmut Spreitzer (Author), Peter Wolschann (Author), Supa Hannongbua (Author), Anuchit Plubrukarn (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of scalarane sesterterpenes were prepared using heteronemin (<b>1</b>) as a primary precursor. Combined with the scalarane derivatives obtained from natural sources, a total of 22 antitubercular scalaranes were used to build QSAR models based in the 2D-QSAR and CoMFA approaches....