Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model

• Main Authors: Flavia Storelli (Author), Mayur K. Ladumor (Author), Xiaomin Liang (Author), Yurong Lai (Author), Paresh P. Chothe (Author), Osatohanmwen J. Enogieru (Author), Raymond Evers (Author), Jashvant D. Unadkat (Author)
• Format: Book
• Published: Wiley, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Hepatic impairment (HI) moderately (<5‐fold) affects the systemic exposure (i.e., area under the plasma concentration-time curve [AUC]) of drugs that are substrates of the hepatic sinusoidal organic anion transporting polypeptide (OATP) transporters and are excreted unchanged in the bile...