Efficient Transdermal Delivery of Alendronate, a Nitrogen-Containing Bisphosphonate, Using Tip-Loaded Self-Dissolving Microneedle Arrays for the Treatment of Osteoporosis

• Main Authors: Hidemasa Katsumi (Author), Yutaro Tanaka (Author), Kaori Hitomi (Author), Shu Liu (Author), Ying-shu Quan (Author), Fumio Kamiyama (Author), Toshiyasu Sakane (Author), Akira Yamamoto (Author)
• Format: Book
• Published: MDPI AG, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). We observed micron-sc...