Enantiospecific antitrypanosomal in vitro activity of eflornithine.

• Main Authors: Mikael Boberg (Author), Monica Cal (Author), Marcel Kaiser (Author), Rasmus Jansson-Löfmark (Author), Pascal Mäser (Author), Michael Ashton (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The polyamine synthesis inhibitor eflornithine is a recommended treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage. This parasitic disease, transmitted by the tsetse fly, is lethal unless treated. Eflornithine is administered by repeated intravenous infu...