Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

• Main Authors: Reda G. Yousef (Author), Alaa Elwan (Author), Ibraheem M. M. Gobaara (Author), Ahmed B. M. Mehany (Author), Wagdy M. Eldehna (Author), Souad A. El-Metwally (Author), Bshra A. Alsfouk (Author), Eslam B. Elkaeed (Author), Ahmed M. Metwaly (Author), Ibrahim H. Eissa (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the highest anti-proliferative activities with IC50 values of 15.4 and 9.8 µM against HCT-116 and HepG2, respectively compared to sorafenib (IC5...