Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling

• Main Authors: Chunnuan Wu (Author), Bole Li (Author), Shuai Meng (Author), Linghui Qie (Author), Jie Zhang (Author), Guopeng Wang (Author), Cong Cong Ren (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to apply a physiologically based pharmacokinetic (PBPK) model to predict optimal dosing regimens of pazopanib (PAZ) for safe and effective administration when co-administered with CYP3A4 inhibitors, acid-reducing agents, food, and administered in patients with hepatic impairment. He...