Shikonin reactivates TSGs GADD45B and PPP3CC to block NSCLC cell proliferation and migration through JNK/P38/MAPK signaling pathways

• Ngā kaituhi matua: Yujia Zhao (Author), Dan Wu (Author), Zhenkai Fu (Author), Wenna Liu (Author), Yu Yao (Author), Ying Liang (Author)
• Hōputu: Pukapuka
• I whakaputaina: BMC, 2024-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Abstract Background Shikonin, a natural naphthoquinone compound extracted from the Chinese traditional herbal medicine "Lithospermum erythrorhizon", possesses antitumor activity against various cancer types. Tumor-suppressor genes (TSGs) negatively regulate cell growth, proliferation, and...