Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine.

• Main Authors: Inês Loureiro (Author), Joana Faria (Author), Christine Clayton (Author), Sandra Macedo Ribeiro (Author), Nilanjan Roy (Author), Nuno Santarém (Author), Joana Tavares (Author), Anabela Cordeiro- (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Asparagine synthetase (AS) catalyzes the ATP-dependent conversion of aspartate into asparagine using ammonia or glutamine as nitrogen source. There are two distinct types of AS, asparagine synthetase A (AS-A), known as strictly ammonia-dependent, and asparagine synthetase B (AS-B), which can use eit...