Inhibition of Alk signaling promotes the induction of human salivary-gland-derived organoids

• Main Authors: Shohei Yoshimoto (Author), Junko Yoshizumi (Author), Hiromasa Anzai (Author), Koichiro Morishita (Author), Kazuhiko Okamura (Author), Akimitsu Hiraki (Author), Shuichi Hashimoto (Author)
• Format: Book
• Published: The Company of Biologists, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyposalivation and xerostomia are the cause of several morbidities, such as dental caries, painful mucositis, oral fungal infections, sialadenitis and dysphagia. For these reasons, preservation of normal saliva secretion is critical for the maintenance of functionally normal oral homeostasis and for...