Dietary advanced glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs

• Main Authors: Divya Krishnamoorthy (Author), Robert C. Hoy (Author), Devorah M. Natelson (Author), Olivia M. Torre (Author), Damien M. Laudier (Author), James C. Iatridis (Author), Svenja Illien-Jünger (Author)
• Format: Bog
• Udgivet: The Company of Biologists, 2018-12-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Back pain is a leading cause of disability and is strongly associated with intervertebral disc (IVD) degeneration. Reducing structural disruption and catabolism in IVD degeneration remains an important clinical challenge. Pro-oxidant and structure-modifying advanced glycation end-products (AGEs) con...