Concerns for efficacy of a 30-valent M-protein-based Streptococcus pyogenes vaccine in regions with high rates of rheumatic heart disease.

• Main Authors: Philip M Giffard (Author), Steven Y C Tong (Author), Deborah C Holt (Author), Anna P Ralph (Author), Bart J Currie (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prevalence of rheumatic heart disease (RHD) in the Aboriginal population of the Australian Northern Territory is high, and Streptococcus pyogenes skin infections likely contribute to this. A promising candidate S. pyogenes "30mer" vaccine is composed of 30 pharyngitis associated type-s...