Combination Effect of GSTM1, GSTT1 and GSTP1 Polymorphisms and Risk of Systemic Lupus Erythematosus

• Main Authors: Saeedeh SALIMI (Author), Alireza NAKHAEE (Author), Mehdi JAFARI (Author), Danial JAHANTIGH (Author), Mahnaz SANDOOGHI (Author), Zahra ZAKERI (Author), Mahnaz SHAHRAKIPOUR (Author), Anoosh NAGHAVI (Author), Farzaneh FARAJIAN- MASHHADI (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Progression of systemic lupus erythematosus (SLE) could be due to oxidative stress especially through reactive oxygen species (ROS). Detoxification of ROS is largely performed by Glutathione S-transferases (GSTs), therefore polymorphisms of GSTM1, GSTT1 and GSTP1 genes which decrease enz...