A Self-Emulsified Adjuvant System Containing the Immune Potentiator Alpha Tocopherol Induces Higher Neutralizing Antibody Responses than a Squalene-Only Emulsion When Evaluated with a Recombinant Cytomegalovirus (CMV) Pentamer Antigen in Mice

• Main Authors: Rushit N. Lodaya (Author), Amey P. Kanitkar (Author), Asma Ashraf (Author), Douty Bamba (Author), Mansoor M. Amiji (Author), Derek T. O'Hagan (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2023-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The development of new vaccine adjuvants represents a key approach to improvingi the immune responses to recombinant vaccine antigens. Emulsion adjuvants, such as AS03 and MF59, in combination with influenza vaccines, have allowed antigen dose sparing, greater breadth of responses and fewer immuniza...