Intranasal delivery of Clozapine using nanoemulsion-based in-situ gels: An approach for bioavailability enhancement

• Autori principali: Nourhan A. Abdulla (Autore), Gehan F. Balata (Autore), Hanaa A. El-ghamry (Autore), Eman Gomaa (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2021-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Limited solubility and hepatic first-pass metabolism are the main causes of low bioavailability of anti-schizophrenic drug, Clozapine (CZP). The objective of the study was to develop and validate nanoemulsion (NE) based in-situ gel of CZP for intranasal administration as an approach for bioavailabil...