Intranasal delivery of Clozapine using nanoemulsion-based in-situ gels: An approach for bioavailability enhancement
Limited solubility and hepatic first-pass metabolism are the main causes of low bioavailability of anti-schizophrenic drug, Clozapine (CZP). The objective of the study was to develop and validate nanoemulsion (NE) based in-situ gel of CZP for intranasal administration as an approach for bioavailabil...
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Main Authors: | Nourhan A. Abdulla (Author), Gehan F. Balata (Author), Hanaa A. El-ghamry (Author), Eman Gomaa (Author) |
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Format: | Book |
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Elsevier,
2021-12-01T00:00:00Z.
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Online Access: | Connect to this object online. |
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