Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway

• Main Authors: Xuyun Liu (Author), Jing Gao (Author), Yizhen Yan (Author), Eleftheria A. Georgiou (Author), Jing Lou (Author), Mengya Feng (Author), Xing Zhang (Author), Feng Gao (Author), Jiankang Liu (Author), Ioannis K. Kostakis (Author), Lin Zhao (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperlipidemia results in endothelial dysfunction, which is intimately associated with disturbed mitochondrial homeostasis, and is a real risk factor for cardiovascular diseases (CVDs). Triphenylphosphonium (TPP⁺)-HT, constructed by linking a mitochondrial-targeting moiety TPP...