c-Abl Inhibition Exerts Symptomatic Antiparkinsonian Effects Through a Striatal Postsynaptic Mechanism

• Main Authors: Yu Zhou (Author), Yukio Yamamura (Author), Masatoshi Ogawa (Author), Ryosuke Tsuji (Author), Koichiro Tsuchiya (Author), Jiro Kasahara (Author), Satoshi Goto (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is caused by a progressive degeneration of nigral dopaminergic cells leading to striatal dopamine deficiency. From the perspective of antiparkinsonian drug mechanisms, pharmacologic treatment of PD can be divided into symptomatic and disease-modifying (neuroprotective)...