NF1 deficiency drives metabolic reprogramming in ER+ breast cancer

• Main Authors: Rachel (Rae) (Author), Elizabeth A. Tovar (Author), Luke N. Redlon (Author), Curt J. Essenburg (Author), Patrick S. Dischinger (Author), Abigail E. Ellis (Author), Ian Beddows (Author), Ryan D. Sheldon (Author), Evan C. Lien (Author), Carrie R. Graveel (Author), Matthew R. Steensma (Author)
• Formato: Libro
• Publicado: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Objective: NF1 is a tumor suppressor gene and its protein product, neurofibromin, is a negative regulator of the RAS pathway. NF1 is one of the top driver mutations in sporadic breast cancer such that 27 % of breast cancers exhibit damaging NF1 alterations. NF1 loss-of-function is a frequent event i...