Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators

• Main Authors: Ravikumar Manickam (Author), Jared Tur (Author), Sachin L. Badole (Author), Kalyan C. Chapalamadugu (Author), Puja Sinha (Author), Zhiying Wang (Author), David W. Russ (Author), Marco Brotto (Author), Srinivas M. Tipparaju (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Nicotinamide phosphoribosyltransferase (Nampt), a key enzyme in NAD salvage pathway is decreased in metabolic diseases, and its precise role in skeletal muscle function is not known. We tested the hypothesis, Nampt activation by P7C3 (3,6‐dibromo‐α‐[(phenylamino)methyl]‐9H‐carbaz...