Optimization of Liposomes for Antigen Targeting to Splenic CD169⁺ Macrophages

• Main Authors: Maarten K. Nijen Twilhaar (Author), Lucas Czentner (Author), Joanna Grabowska (Author), Alsya J. Affandi (Author), Chun Yin Jerry Lau (Author), Katarzyna Olesek (Author), Hakan Kalay (Author), Cornelus F. van Nostrum (Author), Yvette van Kooyk (Author), Gert Storm (Author), Joke M.M. den Haan (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite promising progress in cancer vaccination, therapeutic effectiveness is often insufficient. Cancer vaccine effectiveness could be enhanced by targeting vaccine antigens to antigen-presenting cells, thereby increasing T-cell activation. CD169-expressing splenic macrophages efficiently capture...