A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose

• Main Authors: James W Dear (Author), Mei Li Ng (Author), D. Nicholas Bateman (Author), Pakkiri Leroy Sivappiragasam (Author), Hyungwon Choi (Author), Benjamin Bing Jie Khoo (Author), Baharudin Ibrahim (Author), Chester Lee Drum (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites,...