Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency

Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency

The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. In a 46, XY patient with female external genitalia, together with a loss of function mutation S441P, we identified a novel...

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Main Authors: Mónica Fernández-Cancio (Author), Núria Camats (Author), Christa E. Flück (Author), Adam Zalewski (Author), Bernhard Dick (Author), Brigitte M. Frey (Author), Raquel Monné (Author), Núria Torán (Author), Laura Audí (Author), Amit V. Pandey (Author)
Format: Book
Published: MDPI AG, 2018-04-01T00:00:00Z.
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