Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation
Abstract The ratio of the longer (Aβ42/Aβ43) to shorter (Aβ40) species is a critical factor determining amyloid fibril formation, neurotoxicity and progression of the amyloid pathology in Alzheimer's disease. The relative levels of the different Aβ species are affected by activity and conformat...
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Format: | Book |
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BMC,
2016-07-01T00:00:00Z.
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A1234.567 |
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